TIPS TO MANAGE MENTAL HEALTH
THEOPHYLLINE TOXICITY, SPECIFIC INGESTION & TREATMENT :
THEOPHYLLINE
TOXICITY, SPECIFIC INGESTION & TREATMENT :
THEOPHYLLINE
:
Intro of Drug :
- Theophylline occurs in tea and cocoa beans in trace amounts.
Available
dosage forms:
- Liquid sustained-release tabs, caps & parenteral.
Toxicokinetics:
·
Well absorbed Orally Volume of distribution approx.0.5L/Kg
· Hepatically metabolized
·
Clearance
depends on age, disease states & interacting drugs.
Clinical
Presentation:
· a feeling of loathing
·
Vomit
· Convulsion
·
Cardiac
Dysrhythmias
·
Chronic
toxicity
Laboratory
Data:
A- Theophylline levels: 5 to 20µg/ml
B-
Hyperglycemia and Hypoglycemia: after acute ingestion
C- Other tests include: Serum Electrolytes, BUN, Creatinine, Hepatic Function, ECG Monitoring
Treatment:
1-Supportive
Therapy:
·
Maintaining airway
·
seizures Treatment
·
Dysrhythmia Treatment
2- Decontamination: Syrup of Ipecac not Recommended
3-Activated
Charcoal:
·
Repeated doses to increase Elimination
· Whole-Bowl Irrigation (For sust. release)
·
Charcoal Hemoperfusion: unstable patient in status epileptics
· Hemodialysis: When hemoperfusion is
unavailable
4- β-Adrenergic Antagonists:
· used to treat Hypotension, Tachycardia, Dysrhythmias
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