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H2 RECEPTOR ANTAGONIST TOXICITY, SPECIFIC INGESTION & TREATMENT
H2 RECEPTOR ANTAGONIST
TOXICITY, SPECIFIC INGESTION & TREATMENT:
H2 RECEPTOR ANTAGONIST:
Intro
of Drugs:
· Reduce acids which are produced by the Lining of the Stomach
· Include cimetidine, famotidine, nizatidine, ranitidine
Available
dosage forms:
· Oral Route, IV route
Toxicokinetics:
· Therapeutic
Bioavailability Cimetidine:60-70%
· Therapeutic
Bioavailability famotidine: 40-45%
· Therapeutic
Bioavailability nizatidine:90-100%
· Therapeutic Bioavailability ranitidine:50-60%
Clinical
Presentation:
- irregular heartbeat.
- Confusion
- Diarrhea
- Dyspnea
- Dilated pupils
- Drowsiness
- Flushing
- Low blood pressure
- Nausea
- Rapid heartbeat or slow
heartbeat
- Slurred speech
- Sweating
Interactions:
· Cimetidine binds with Cytochrome p450, interfere metabolism of drugs such as phenytoin, theophylline, Phenobarbital, lidocaine, warfarin, diazepam, imipramine, propanolol
Precautions & Monitoring:
1-Ranitidine caution for hepatic
impairment patients.
2-Cimetidine can cause Thrombocytopenia, agranulocytosis
Treatment:
Monitor a person's vital signs, like temperature, pulse, breathing rate, and blood
pressure. Symptoms will be treated.
The person may
receive:
- Activated charcoal
- Blood and urine tests
- Breathing support, including
oxygen
- Chest x-ray
- EKG (electrocardiogram)
- Intravenous fluids (through a
vein)
- A laxative
- Medicine to treat symptoms
- Gastric lavage
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